stavudine contraindications

Hypersensitivity to stavudine or any component of the formulation; coadministration with didanosine. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Het Farmacotherapeutisch Kompas gebruikt analytische cookies om het gebruik van de website te analyseren en daarmee de website te kunnen verbeteren. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Copyright © 2001 - 2020 Pediatric Oncall All Rights Reserved. Teratogenese: De klinische ervaring is beperkt, maar aangeboren abnormaliteiten en miskramen zijn gemeld. Avoid concurrent admin with drugs that cause pancreatitis (e.g. Indication : • For the treatment of HIV infection. Identify these contraindicated and dangerous stavudine oral (Zerit Oral) drug combinations to avoid with the RxList drug interaction checker tool. Oral Cl decreases and terminal elimination half-life increases in patients with renal insufficiency. door oxidering en glucuronidering. Keep out of the reach of children. Wees hierbij voorzichtig, in verband met meer kans op ontstekingsreacties op latent aanwezige opportunistische infecties, met ernstige klinische ziektebeelden tot gevolg (zoals CMV-retinitis, focale en/of gegeneraliseerde mycobacteriële infecties of een Pneumocystis jiroveci-pneumonie). De behandelduur zo kort mogelijk houden en zo mogelijk omschakelen naar een andere behandeling. Reconstitute powder for oral suspension with 202 mL of purified water as specified on the bottle. Note: Stavudine is no longer recommended for use in the treatment of HIV (HHS [adult] 2019). Hepatotoxicity or lactic acidosis, including fatal cases, have been reported with the use of stavudine. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. How Long Does Coronavirus Live On Surfaces? De duur van de behandeling dient in verband met het bijwerkingenprofiel zo kort mogelijk te zijn. • Lipoatrophy: May cause loss of subcutaneous fat, especially in the face, limbs, and buttocks. If pancreatitis diagnosis is confirmed, use extreme caution if reinitiating stavudine; monitor closely and do not use didanosine in regimen. Avoid combination, DOXOrubicin (Conventional): May diminish the therapeutic effect of Stavudine. Sign Up to Receive Our Free Coroanvirus Newsletter, increased blood acidity due to high levels of lactic acid, a painful condition that affects the nerves in the legs and arms called peripheral neuropathy, a mother who is producing milk and breastfeeding, chronic kidney disease stage 3A (moderate), chronic kidney disease stage 3B (moderate), kidney disease with likely reduction in kidney function. ART should be continued postpartum for all females living with HIV and can be modified after delivery. Store away from heat and direct light. • Lactic acidosis/hepatomegaly: [US Boxed Warning]: Lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogues, including fatal cases; coadministration of stavudine and didanosine is contraindicated. Use with hydroxyurea should be avoided; coadministration with didanosine is contraindicated. Bij verergering van de leverziekte de behandeling onderbreken of staken. Dose as in GFR<25 mL/min, Unknown dialysability. Monitor therapy, DOXOrubicin (Liposomal): May diminish the therapeutic effect of Stavudine. Note: The manufacturer's labeling (40 mg) is not recommended due to a greater incidence of adverse effects (HHS [pediatric] 2018). Stavudine SELECT Concise Prescribing Info Full Prescribing Info Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Food Interaction Action Storage CIMS Class ATC Classification Stavudine - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Verminderde nierfunctie: overweeg een reductie van de dosis en/of een langer toedieningsinterval; er zijn géén dosisaanbevelingen voor kinderen < 3 maanden met een verminderde nierfunctie. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer. HIV nucleoside reverse-transcriptaseremmers, Informatie van Lareb over dit middel bij zwangerschap, Informatie van Lareb over dit middel bij lactatie. Dosage should be carefully adjusted to renal function. Verhoging ALAT-, ASAT- en lipasewaarden. Encyclopedia section of medindia gives general info about AIDS information and health education. Because there is clear benefit to appropriate treatment, maternal ART should not be withheld due to concerns for adverse neonatal outcomes. Contraindications. Advies: Alleen op strikte indicatie gebruiken. Zie voor contra-indicaties de rubriek Interacties. Fatal and nonfatal pancreatitis has occurred during therapy with stavudine. All trademarks used are the properties of their respective owners. Klap alles open Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2020. Some products may contain sucrose. Hypersensitivity to stavudine or any component of the formulation; coadministration with didanosine. This medication is a nucleoside analog reverse transcriptase inhibitor (NARTI), prescribed for HIV/AIDS. Soms (0,1-1%): angst, emotionele labiliteit. AIDS has taken on massive proportions in modern times. Farmacologisch effect: Mitochondriale disfunctie is gemeld bij HIV-negatieve kinderen die in utero en/of postnataal zijn blootgesteld aan nucleoside-analoga, met als gevolg meestal voorbijgaande hematologische (anemie, neutropenie) en metabole (hyperlipasemie en hyperlactatemie) stoornissen en daarnaast, in zeldzame gevallen, laat intredende neurologische stoornissen (hypertonie, convulsies, abnormaal gedrag) waarvan nog niet is bekend of deze tijdelijk of blijvend van aard zijn. Outcome information specific to stavudine use in pregnancy is no longer being reviewed and updated in the Health and Humans Services (HHS) perinatal guidelines. Such insertions do not conform to our, More Information for Doctors about Stavudine, How to Reduce School Bag Weight - Simple Tips, Pharmaceutical, Drug ,Chemist Association - India. Dialysepatiënten dienen de dosis na de dialyse in te nemen en op niet-dialyse dagen op hetzelfde tijdstip. Contraindications; ਪੰਜਾਬੀ Eng हिंदी বাংলা. Toedieningsinformatie: Voor optimale resorptie de capsule op een lege maag innemen (ten minste 1 uur voor de maaltijd); indien dit niet mogelijk is dan innemen met een lichte maaltijd. Health care providers caring for pregnant females living with HIV and their infants may contact the National Perinatal HIV Hotline (888-448-8765) for clinical consultation (HHS [perinatal] 2019). • Caution should be exercised in patients with history of liver or kidney disease, sugar, elderly, during pregnancy and breastfeeding. (Fatale) lactaatacidose. Bij dit geneesmiddel wordt (tevens) gedoseerd op geleide van de bloedspiegel; zie voor meer informatie hierover op HIV-middelen van tdm-monografie.org. Stavudine should be used with caution in patients with known risk factors for hepatic disease. HIV nucleoside reverse-transcriptaseremmers. AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with precautions. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Find out what health conditions may be a health risk when taken with Zerit Oral Final suspension will be 1 mg/mL (200 mL). Coadministration of stavudine and didanosine is contraindicated because of increased risk of serious and/or life-threatening events. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Overig: Het kind (ook HIV-negatieve kinderen) dat in utero is blootgesteld aan stavudine klinisch en middels laboratoriumtesten controleren op tekenen van mitochondriale disfunctie. Gemeld zijn gevallen van osteonecrose, vooral bij gevorderde HIV-infectie of langdurige blootstelling aan cART. Suspend stavudine and any agents toxic to the pancreas in patients with suspected pancreatitis. Avoid combination, Didanosine: Stavudine may enhance the adverse/toxic effect of Didanosine. For males and females living with HIV and planning a pregnancy, maximum viral suppression below the limits of detection with antiretroviral therapy (ART), modification of therapy (if needed), optimization of the woman’s health, and a discussion of the potential risks and benefits of ART therapy during pregnancy is recommended prior to conception (HHS [perinatal] 2019). Based on the HHS perinatal HIV guidelines, stavudine is not one of the recommended antiretroviral agents for use during pregnancy. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Dit geneesmiddel is niet opgenomen in het geneesmiddelen vergoedings systeem (GVS). Dosing : <14 days: 0.5 mg/kg PO every 12 hours. 40% van plasmaconcentratie. Capsules and powder for reconstitution may be stored at controlled room temperature of 25°C (77°F). Medically reviewed by Drugs.com. Fatal lactic acidosis has been reported in pregnant individuals who received the combination of stavudine and didanosine with other antiretroviral agents. Eerste keus in de behandeling van therapie-naïeve volwassen patiënten met een HIV-1-infectie is tripeltherapie bestaande uit een integraseremmer (INSTI) met twee nucleoside reverse-transcriptaseremmers (NRTI’s). Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting. However, many people have no side effects or only have minor side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Older patients should be closely monitored for signs and symptoms of peripheral neuropathy. Malaria: Types, Clinical Features, Diagnosis, Treatment & Drugs | Dr Ira Shah, Esophageal Strictures – Endoscopic Therapy | Dr. Ira Shah, Dr. Ira Shah | Acute Viral Hepatitis - Hepatotrophic vs Non Hepatotrophic Viral Infections, Recurrent hyperbilirubinemia in an infant, A 9 months old child with asymptomatic bradycardia. Lipoatrofie, asymptomatische hyperlactacidemie. [US Boxed Warning]: Fatal lactic acidosis has been reported in pregnant individuals using didanosine and stavudine in combination with other antiretroviral agents; coadministration of stavudine and didanosine is contraindicated. - National Commission on AIDS, 1993. If used, it should be in combination with other ARV agents. May be taken without regard to meals. Suspend treatment in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or hepatotoxicity (transaminase elevation may/may not accompany hepatomegaly and steatosis). Vergelijk de kosten van bovenstaande middelen onderling. | J05AF04. Braken, hepatitis of geelzucht, (fatale) pancreatitis. HIV-1: Treatment of HIV-1 infection in combination with other antiretroviral agents. Monitor liver function tests and renal function tests; signs and symptoms of peripheral neuropathy; monitor viral load and CD4 count.

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